Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis
| Autor: | Regina Bleul, Roland Welz, Thorsten Klein, Abdulkader Baki, Florian Meier, Frank Wiekhorst, Norbert Löwa, Ernst-Albrecht Welge, Dirk Gutkelch |
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| Přispěvatelé: | Publica |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
biomedical applications
magnetic nanoparticles Materials science synthesis General Chemical Engineering Nanoparticle Micromixer Nanotechnology 02 engineering and technology Magnetic particle inspection 01 natural sciences Article lcsh:Chemistry process monitoring magnetic particle spectroscopy 0103 physical sciences General Materials Science 010302 applied physics Spectrometer Detector Magnetic detector 021001 nanoscience & nanotechnology lcsh:QD1-999 Magnetic nanoparticles 0210 nano-technology magnetic characterization Excitation |
| Zdroj: | Nanomaterials, Vol 10, Iss 2277, p 2277 (2020) Nanomaterials Volume 10 Issue 11 |
| ISSN: | 2079-4991 |
| Popis: | Magnetic nanoparticles combine unique magnetic properties that can be used in a variety of biomedical applications for therapy and diagnostics. These applications place high demands on the magnetic properties of nanoparticles. Thus, research, development, and quality assurance of magnetic nanoparticles requires powerful analytical methods that are capable of detecting relevant structural and, above all, magnetic parameters. By directly coupling nanoparticle synthesis with magnetic detectors, relevant nanoparticle properties can be obtained and evaluated, and adjustments can be made to the manufacturing process in real time. This work presents a sensitive and fast magnetic detector for online characterization of magnetic nanoparticles during their continuous micromixer synthesis. The detector is based on the measurement of the nonlinear dynamic magnetic response of magnetic nanoparticles exposed to an oscillating excitation at a frequency of 25 kHz, a technique also known as magnetic particle spectroscopy. Our results underline the excellent suitability of the developed magnetic online detection for coupling with magnetic nanoparticle synthesis based on the micromixer approach. The proven practicability and reliability of the detector for process monitoring forms the basis for further application fields, e.g., as a monitoring tool for chromatographic separation processes. |
| Databáze: | OpenAIRE |
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