Free Triiodothyronine Is Independently Associated with Nonalcoholic Fatty Liver Disease in Hospitalized Type 2 Diabetes Mellitus Patients

Autor: Xiaoying Xia, Yaping Hong, Liangchang Xiu, Shu Li, Rou Shi, Yingjian Chen, Chunwen Lin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
Blood Glucose
Male
medicine.medical_specialty
Article Subject
endocrine system diseases
Population
Blood lipids
030209 endocrinology & metabolism
Type 2 diabetes
Logistic regression
Gastroenterology
digestive system
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Internal medicine
Nonalcoholic fatty liver disease
medicine
Humans
Risk factor
education
Aged
education.field_of_study
General Immunology and Microbiology
business.industry
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
General Medicine
Middle Aged
medicine.disease
Lipids
digestive system diseases
Hospitalization
Cross-Sectional Studies
Diabetes Mellitus
Type 2
Triiodothyronine
Medicine
030211 gastroenterology & hepatology
Liver function
business
Research Article
Zdroj: BioMed Research International, Vol 2021 (2021)
BioMed Research International
ISSN: 2314-6141
2314-6133
Popis: Objective. Free triiodothyronine (FT3) is an independent risk factor for nonalcoholic fatty liver disease (NAFLD) in patients with euthyroid. However, whether FT3 has an independent effect on NAFLD in a population of type 2 diabetes remains unknown. The purpose of this study was to identify the potential role of FT3 in NAFLD with T2DM. Design. A cross-sectional study. Patient. A total of 859 T2DM patients who met the inclusion criteria were included. There were 506 T2DM patients without NAFLD and 353 T2DM patients with NAFLD. Methods. The independent samples t -test or Wilcoxon rank sum test were used for continuous variables of different distribution types, while the chi-square test was used for categorical variables. Pearson correlation analysis and linear regression were used to analyze the correlation between FT3 and clinical measurements and biochemical indicators. Multivariate logistic regression analysis was used to determine independent predictors. Results. Patients with NAFLD had higher BMI, SBP, and DBP, longer duration of T2DM, and higher islet function index, blood glucose index, liver function index, renal function index, blood lipid index, and FT3. We also found that FT3 was affected by other five indicators, including ALT, CR, GGT, TC, and LDL-C only in the NAFLD group but not in the non-NAFLD group. FT3 was significantly associated with NAFLD in T2DM patients, and the prevalence of NAFLD increased gradually from the lowest FT3 tertile to the highest FT3 tertile ( P for trend < 0.001 ). Conclusion. FT3 is independently associated with NAFLD in hospitalized T2DM patients after rigorous adjustment for various metabolic parameters.
Databáze: OpenAIRE
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