Neuroaxonal Dystrophy in Australian Merino Lambs
| Autor: | Allan Kessell, John W. Finnie, Peter C. Blumbergs, Jim Manavis, I.V. Jerrett |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Nervous system Pathology medicine.medical_specialty Neuroaxonal Dystrophies Vision Disorders Sheep Diseases Neuropathology Biology Axonal Transport Pathology and Forensic Medicine Myelin loss Immunoenzyme Techniques medicine Animals Gliosis Neuroaxonal dystrophy Medulla Oblongata Sheep General Veterinary medicine.anatomical_structure Morphological abnormality Axoplasmic transport Female NAD+ kinase medicine.symptom Biomarkers Demyelinating Diseases |
| Zdroj: | Journal of Comparative Pathology. 147:62-72 |
| ISSN: | 0021-9975 |
| Popis: | Neuroaxonal dystrophy (NAD) is a morphological abnormality in man and animals that is characterized by the occurrence of numerous axonal swellings (spheroids) in the nervous system. NAD has been described in Suffolk lambs in the USA, Merino lambs in Australia and several breeds of sheep in New Zealand. This paper describes the clinicopathological changes of only the second occurrence of NAD reported in Merino lambs. There were some features (myelin loss, gliosis and visual impairment) in these Australian cases that have not been reported previously in ovine NAD. Application of immunohistochemical markers of axonal transport suggested that disruption of this transport mechanism contributed to spheroid development. |
| Databáze: | OpenAIRE |
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