A systematic review of the effects of increasing arachidonic acid intake on PUFA status, metabolism and health-related outcomes in humans
| Autor: | Ans Eilander, Bert J. M. van de Heijning, Szimonetta Lohner, Cristina Campoy, Per-Olof Larsson, Stewart Forsyth, Aliz Szommer, Mathilde Fleith, Ronald P. Mensink, Bettina Schelkle, Philip C. Calder |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male BLOOD Medicine (miscellaneous) Physiology Blood lipids ARA arachidonic acid law.invention chemistry.chemical_compound Randomized controlled trial LC-PUFA long-chain PUFA law Medicine DGLA dihomo-γ-linolenic acid heterocyclic compounds RESISTANCE EXERCISE PLATELET LA linoleic acid Randomized Controlled Trials as Topic POLYUNSATURATED FATTY-ACIDS chemistry.chemical_classification FA fatty acid Nutrition and Dietetics Arachidonic Acid n-6 Fatty acids PL phospholipid food and beverages RCT randomised controlled trial CE cholesteryl ester Middle Aged Arachidonic acid Fatty Acids Unsaturated Female lipids (amino acids peptides and proteins) DIETARY SUPPLEMENTATION Polyunsaturated fatty acid Adult LONG-CHAIN N-3 EICOSANOIDS Linoleic acid Nutritional Status 03 medical and health sciences Humans CELL Fatty acids Adverse effect Aged Inflammation 030109 nutrition & dietetics Dihomo-γ-linolenic acid business.industry Human health Fatty acid DOCOSAHEXAENOIC ACID biochemical phenomena metabolism and nutrition carbohydrates (lipids) 030104 developmental biology chemistry Dietary Supplements business |
| Zdroj: | Digibug. Repositorio Institucional de la Universidad de Granada instname |
| Popis: | We conducted a systematic review of randomised controlled trials (RCT) of increased intake of arachidonic acid (ARA) on fatty acid status and health outcomes in humans. We identified twenty-two articles from fourteen RCT. Most studies were conducted in adults. These used between 80 and 2000 mg ARA per d and were of 1–12 weeks duration. Supplementation with ARA doses as low as 80 mg/d increased the content of ARA in different blood fractions. Overall there seem to be few marked benefits for adults of increasing ARA intake from the typical usual intake of 100–200 mg/d to as much as 1000 mg/d; the few studies using higher doses (1500 or 2000 mg/d) also report little benefit. However, there may be an impact of ARA on cognitive and muscle function which could be particularly relevant in the ageing population. The studies reviewed here suggest no adverse effects in adults of increased ARA intake up to at least 1000–1500 mg/d on blood lipids, platelet aggregation and blood clotting, immune function, inflammation or urinary excretion of ARA metabolites. However, in many areas there are insufficient studies to make firm conclusions, and higher intakes of ARA are deserving of further study. Based on the RCT reviewed, there are not enough data to make any recommendations for specific health effects of ARA intake. |
| Databáze: | OpenAIRE |
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