Clinical characteristics of HIV-1-infected patients with high levels of plasma interferon-γ: a multicenter observational study

Autor: Erina Matsumoto, Takuma Shirasaka, Dai Watanabe, Morio Sawamura, Masahiro Yamamoto, Tomoko Uehira, Kimikazu Hayashi, Takashi Ueji, Soichiro Takahama, Rumi Minami, Kazuyuki Hirota, Sachiko Suzuki
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
CD4-Positive T-Lymphocytes
Male
0301 basic medicine
medicine.medical_specialty
030106 microbiology
Human immunodeficiency virus (HIV)
HIV Infections
HIV-1 infection
medicine.disease_cause
Gastroenterology
lcsh:Infectious and parasitic diseases
Interferon-gamma
03 medical and health sciences
0302 clinical medicine
Medical microbiology
Interferon γ
Interferon
Internal medicine
Drug Resistance
Viral
HIV Seropositivity
medicine
Humans
lcsh:RC109-216
030212 general & internal medicine
Viral suppression
Interleukin 6
biology
business.industry
Interleukin-6
Middle Aged
medicine.disease
CD4 Lymphocyte Count
Infectious Diseases
Anti-Retroviral Agents
HIV-1
biology.protein
RNA
Viral
Female
Observational study
Interferon-γ
CD4+ cell count recovery
business
Dyslipidemia
Research Article
medicine.drug
Zdroj: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Infectious Diseases
ISSN: 1471-2334
DOI: 10.1186/s12879-018-3643-2
Popis: Background Circulating interferon-γ (IFN-γ) concentration may be sustained at a high level regardless of the initiation of antiretroviral therapy (ART) in some patients with HIV-1 infection. In the present study, we examined the clinical characteristics of HIV-1-infected patients with high levels of plasma IFN-γ. Methods The study subjects were patients infected with HIV-1 who were either naïve to ART with CD4+ cell count > 200 cells/μL (n = 12), or had achieved viral suppression after ART for over a year (n = 188). The levels of plasma IFN-γ and interleukin-6 (IL-6) were measured by the enzyme-linked immunosorbent assay. Patients were divided into high IFN-γ and low IFN-γ groups based on a cutoff level of 5 pg/mL. Results The high IFN-γ group included 41 patients (21%). Compared to the patients on ART with low IFN-γ levels, those on ART in the high IFN-γ group were more likely to be younger than 50 years of age (P = 0.0051) and less likely to have dyslipidemia (P = 0.0476) or to be on a protease inhibitor (P = 0.0449). There was no significant difference between groups in the median increase of CD4+ cell counts from the initiation of ART for up to 3 years. However, after 4 years, the increase in CD4+ cell counts was significantly lower in the high IFN-γ group compared with that in the low IFN-γ group. There were no such significant differences between patients with low and high (> 2 pg/mL) levels of plasma IL-6. Conclusion We concluded that HIV-1-infected patients with high levels of circulating IFN-γ did not have a higher rate of comorbidities related to immune activation. However, they exhibited lower CD4+ cell count recovery after 4 years of being on ART. This deficit could be a consequence of persistent immune activation. Electronic supplementary material The online version of this article (10.1186/s12879-018-3643-2) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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