An Immunochemical Study of Pigeon-Breeder’s Disease

Autor:	L. Berrens, C.L.H. Guikers
Rok vydání:	1972
Předmět:	Immunology food and beverages Immunology and Allergy hemic and immune systems chemical and pharmacologic phenomena General Medicine
Zdroj:	International Archives of Allergy and Immunology. 43:337-346
ISSN:	1423-0097 1018-2438
DOI:	10.1159/000230849
Popis:	Experimental evidence is provided to show that ‘classical’ C3 in the serum of patients with pigeon-fancier’s lung – in its acute, subacute or chronic form – is rapidly depleted by incubation with antigens from pigeon excreta. The most effective antigens, which are active in the nanogram range, reside among the aspecifically-precipitating ‘A’ heteropolysaccharides. With the aid of an R3 reagent, a simple laboratory test has been developed which is highly significant for pigeon-breeder’s disease (PBL). The results indicate that C3 inactivation in the serum of these patients is mediated by the – unusually labile – bypass mechanism of complement consumption, without participation of the early components. A discussion is given of the possible contributions of the various antigens in pigeon excreta to the mechanisms of pathogenesis of PBL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f28ebcebc6da150c8481fc5e7da8a8 https://doi.org/10.1159/000230849 Zobrazit plný text záznamu