A MONOCLONAL ANTI-PAN-T-CELL ANTIBODY IN VITRO AND IN VIVO STUDIES
| Autor: | P. J. Thurlow, Anthony J F D'Apice, E. K. Lovering, Ian F. C. McKenzie |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Graft Rejection
Rosette Formation medicine.drug_class T-Lymphocytes T cell Receptors Antigen T-Cell Monoclonal antibody Binding Competitive Antigen-Antibody Reactions Mice chemistry.chemical_compound Antigen Null cell medicine Animals Humans Pan-T antigens Transplantation biology Immunization Passive Antibodies Monoclonal Infant Macaca mulatta Molecular biology Sialic acid Molecular Weight Macaca fascicularis medicine.anatomical_structure chemistry Monoclonal biology.protein Macaca nemestrina Antibody Peptide Hydrolases |
| Zdroj: | Transplantation. 36:293-297 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-198309000-00013 |
| Popis: | A murine monoclonal antihuman T cell antibody is described that is pan-T in that it reacts with all T cells, including those from thymus, but not with B cells or other cells, except for a small subpopulation of null cells. Biochemical analysis demonstrated that the antigen detected is a glycoprotein, Mr 50,000 daltons, in which sialic acid, alpha-fucose and alpha-mannose are the important terminal or subterminal carbohydrates. Further analysis indicated that the antigen is the E-rosette-forming-cell (ERFC) receptor or a closely associated structure. Three patients with renal allograft rejection were treated with the pan-T cell monoclonal antibody and, although the antibody was in excess and bound to circulating T cells, no lasting effect on T cell numbers or graft rejection was noted. |
| Databáze: | OpenAIRE |
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