Nitric oxide does not mediate flow induced endothelium dependent arterial dilatation in the cat
| Autor: | Alexandr N Klimachev, Sergey P. Kartamyshev, Vladimir M. Khayutin, Arthur M Melkumyants, Sergey A. Balashov |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Physiology Vasodilation Blood Pressure Femoral artery Arginine Nitric Oxide Nitric oxide chemistry.chemical_compound Physiology (medical) medicine.artery Internal medicine Medicine Animals omega-N-Methylarginine business.industry Acetylcholine Femoral Artery medicine.anatomical_structure Endocrinology Blood pressure NG-Nitroarginine Methyl Ester chemistry Regional Blood Flow Anesthesia Dilator Circulatory system Cats Female Endothelium Vascular Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Cardiovascular research. 26(3) |
| ISSN: | 0008-6363 |
| Popis: | Objective: The aim was to determine whether the endothelium derived nitric oxide formed from L-arginine is the factor which mediates flow induced dilatation of conduit arteries. Methods: Changes in diameter of feline femoral artery caused by blood flow rate increases, acetylcholine, and ATP were recorded during perfusion with blood in situ before and after the inhibition of endothelium derived nitric oxide synthesis by NG-nitro-L-arginine methyl ester and NG-monomethyl-L-arginine. Fourteen anaesthetised cats of either sex, weight 2.6-3.9 kg, were used for the studies. Results: Intravenous administration of NG-nitro-L-arginine methyl ester and NG-monoethyl-L-arginine in doses 10 and 30 mg·kg−1 evoked a rise in mean systemic arterial pressure, constriction of the femoral artery, and considerable decrease in acetylcholine and ATP induced dilatation. However, it did not affect the dilator response induced by increased blood flow rate. Conclusions: Flow induced endothelium dependent arterial dilatation is not mediated by nitric oxide or, if nitric oxide is still released in response to flow rate increase, it has a source distinct from L-arginine. |
| Databáze: | OpenAIRE |
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