Central nervous system activity of a novel class of annelated 1,4-benzodiazepines, aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-ones
| Autor: | G. W. Danswan, I. R. Ager, Peter D. Kennewell, David Kay, John B. Taylor, D. R. Harrison |
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| Rok vydání: | 1977 |
| Předmět: |
Male
Benzodiazepinones Electroshock Chemistry Stereochemistry Central nervous system Drug Synergism Hexobarbital Strychnine Motor Activity Chlorprothixene Aggression Mice medicine.anatomical_structure Anti-Anxiety Agents Drug Discovery medicine Molecular Medicine Animals Humans Pentylenetetrazole Anticonvulsants Cns activity |
| Zdroj: | Journal of medicinal chemistry. 20(8) |
| ISSN: | 0022-2623 |
| Popis: | The synthesis and CNS activity of a noval class of annelated 1,4-benzodiazepines, the aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepines, are described. An investigation of the structure--activity relationships in the series derived from 8-chloro-2,4-dihydro-2-dimethylaminomethylene-6-phenyl-1H-imidazo[1,2-a][1,4]-benzodiazepin-1-one (10) led to the synthesis of a group of compounds with potent minor tranquillizer activity. |
| Databáze: | OpenAIRE |
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