Hepatitis B core related antigen in relation to intrahepatic and circulating viral markers, before and after combination therapy
| Autor: | Ed Bakker, Robin Erken, Henk W. Reesink, S.B. Willemse, Neeltje A. Kootstra, Hans L. Zaaijer, Bart B. Takkenberg |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Hepatitis B virus medicine.medical_specialty HBsAg Combination therapy Specialties of internal medicine Adefovir HBV pgRNA medicine.disease_cause Antiviral Agents Gastroenterology Viral markers Hepatitis B Chronic Pegylated interferon Internal medicine medicine Humans Prospective Studies Hepatology business.industry virus diseases General Medicine cccDNA Viral Load Hepatitis B medicine.disease Hepatitis B Core Antigens digestive system diseases RC581-951 Liver DNA Viral Female HBcrAg business Viral load Biomarkers Follow-Up Studies medicine.drug |
| Zdroj: | Annals of Hepatology, Vol 26, Iss, Pp 100540-(2021) |
| ISSN: | 1665-2681 |
| DOI: | 10.1016/j.aohep.2021.100540 |
| Popis: | Introduction and Objectives: Covalently closed circular (ccc)DNA acts as a viral reservoir in the liver of patients with a chronic hepatitis B (CHB) infection and can only be quantified in liver biopsies. Hepatitis B core-related antigen (HBcrAg) levels in plasma/serum have been proposed to reflect intrahepatic cccDNA-levels and may therefore monitor treatment efficacy. This study aimed to validate the relationship between HBcrAg and other intrahepatic and circulating viral markers in CHB patients with high viral load, before and after combination treatment. Materials and methods: Plasma/serum levels of HBcrAg, HBsAg, HBV-DNA, and HBV pregenomic RNA (HBV-pgRNA), and intrahepatic cccDNA and HBV-DNA levels and fibrosis scores were measured in 89 CHB patients with HBV-DNA levels of >100,000 copies/mL (17,182 IU/mL). Measurements were done before and after a 48-week treatment with pegylated interferon alfa-2a and adefovir in a prospective study (ISRCTN77073364). Results: Baseline HBcrAg-values correlated strongly with intrahepatic cccDNA (ρ 0.77, p |
| Databáze: | OpenAIRE |
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