The association between plasma homocysteine level and metabolic syndrome. A record-based study of Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia
| Autor: | Maha Al Turki, Faris Al Amri, Mohammed Al Hazmi, Mohammed Zeyad Al Yousef, Mujahid Al Shehri, Mazen S. Ferwana, Abdulghani Al Saleb, Abdulkarim Saeed, Fatmah Othman |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Homocysteine HDL education Population Hyperhomocysteinemia Saudi Arabia Comorbidity 030204 cardiovascular system & hematology metabolic syndrome LDL Tertiary Care Centers 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Internal medicine Diabetes mellitus medicine Prevalence Humans 030212 general & internal medicine Aged Aged 80 and over education.field_of_study business.industry Cholesterol HDL Age Factors General Medicine Cholesterol LDL Plasma homocysteine level Anthropometry Middle Aged medicine.disease Confidence interval Cross-Sectional Studies chemistry Population study Female Original Article Metabolic syndrome business Biomarkers |
| Zdroj: | Saudi Medical Journal |
| ISSN: | 0379-5284 |
| Popis: | Objectives: To investigate the association between plasma homocysteine (Hcy) status and metabolic syndrome (MS) among Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia. Methods : A record-based cross-sectional study of 446 patients was carried out. All consecutive plasma Hcy levels from 2015 to 2018 were extracted. International Diabetes Federation criteria for MS were used to classify the patients. A multivariate regression model was developed to examine the associations between plasma Hcy and MS. Results: The mean plasma Hcy level was 10.52 µmol/L, and 40% of the patients exhibited elevated Hcy status. Male patients had significantly elevated Hcy levels compared to female patients ( p less than 0.001). In addition, plasma Hcy levels were significantly higher in patients diagnosed with diabetes ( p =0.021) and hypertension ( p less than 0.001). The prevalence of MS within the study population was 51%. Homocysteine levels were associated with the presence of MS independent of demographic, anthropometric and biochemical variables (odd ratio 1.018; 95% confidence intervals 1.011 -1.047). Conclusion: Plasma Hcy levels were elevated in 40% of the MS patients. Homocysteine had weak association with the presence of MS. Additionally, it was associated with some of its components individually. This study has raised the importance of investigating the association between Hcy status and MS among a representative sample of Saudi population. Additionally, examining possible association and interaction between Hcy level and specific component of MS is suggested to be explored in future studies. Saudi Med J 2020; Vol. 41 (9): 947-954 doi: 10.15537/smj.2020.9.25273 How to cite this article: Saeed A, Al Shehri M, Al Saleb A, Othman F, Al Hazmi M, Al Amri F, Ferwana M, Al Yousef MZ, Al Turki M. The association between plasma homocysteine level and metabolic syndrome. A record-based study of Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia. Saudi Med J. 2020 Sep;41(9):947-954. doi: 10.15537/smj.2020.9.25273. |
| Databáze: | OpenAIRE |
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