Iron Oxide/Salicylic Acid Nanoparticles as Potential Therapy for B16F10 Melanoma Transplanted on the Chick Chorioallantoic Membrane
| Autor: | Dan Eduard Mihaiescu, Ștefana Oana Purcaru, Maria Cristina Predoi, Ion Mîndrilă, Sandra Alice Buteică, O M Mărginean |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Necrosis salicylic acid Bioengineering lcsh:Chemical technology lcsh:Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Chemical Engineering (miscellaneous) Cytotoxic T cell lcsh:TP1-1185 Process Chemistry and Technology Melanoma Therapeutic effect iron oxide nanoparticles xenotransplant B16F10 melanoma medicine.disease CAM assay 030104 developmental biology lcsh:QD1-999 chemistry Apoptosis 030220 oncology & carcinogenesis Cancer research Nanomedicine medicine.symptom Salicylic acid Iron oxide nanoparticles |
| Zdroj: | Processes, Vol 8, Iss 706, p 706 (2020) Processes Volume 8 Issue 6 |
| ISSN: | 2227-9717 |
| Popis: | Unfavorable prognoses and low survival rates are specific features of metastatic melanoma that justify the concern for the development of new therapeutic strategies. Lately, nanotechnology has become an attractive field of study due to recent advances in nanomedicine. Using a chick chorioallantoic membrane (CAM) implanted with xenografts harvested from C57BL/6 mice with B16F10 melanoma cells, we studied the effects of iron oxide nanoparticles functionalized with salicylic acid (SaMNPs) as a form of therapy on the local development of xenotransplants and CAM vessels. The SaMNPs induced an anti-angiogenic effect on the CAM vessels, which accumulated preferentially in the melanoma cells and induced apoptosis and extensive xenograft necrosis. As a result, this slowed the increase in the xenograft volume and reduced the melanoma cells&rsquo ability to metastasize locally and distally. Further, we demonstrate the use of the chick CAM model as a tool for testing the action of newly synthesized nanocomposites on melanoma xenotransplants. The SaMNPs had a therapeutic effect on B16F10 melanoma due to the synergistic action of the two components of its structure: the coating of the salicylic acid with antiangiogenic and chemotherapeutic action and the core of iron oxides with cytotoxic action. |
| Databáze: | OpenAIRE |
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