Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population
| Autor: | Niels E. Skakkebæk, Pal B. Szecsi, Steen Stender, Jacob P. Thyssen, Ulla Nordström Joensen, Jørgen Holm Petersen, Hanne Frederiksen, Anne-Maria Andersson, Niels Jørgensen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urinary system Population Phthalic Acids Parabens Urine 010501 environmental sciences Filaggrin Proteins 01 natural sciences Dermatitis Atopic 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Benzophenones Young Adult 0302 clinical medicine Intermediate Filament Proteins Phenols Loss of Function Mutation Internal medicine medicine Humans education Loss function lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science Genetics lcsh:GE1-350 education.field_of_study integumentary system Atopic dermatitis Environmental Exposure medicine.disease Paraben Endocrinology chemistry Mutation Filaggrin |
| Zdroj: | Environment International, Vol 105, Iss, Pp 105-111 (2017) |
| ISSN: | 0160-4120 |
| Popis: | Background: Filaggrin is an epidermal protein that is important for normal skin barrier functions. Up to 10% of Europeans and Asians carry filaggrin gene (FLG) loss-of function mutations that appear to facilitate trans-epidermal penetration of certain chemicals. We previously showed that mutation carriers have higher internal exposure to certain phthalates, compared to controls, and hypothesized that they could have increased trans-epidermal penetration of other chemicals. Objectives: We investigated exposure to non-persistent chemicals in young Danish men with and without FLG mutations. Methods: Concentrations of eight simple phenols, six parabens and nine UV filters were analysed in urine from 65 FLG loss-of-function mutation carriers and 130 non-carriers (controls). Regression analyses, controlling for urinary dilution and confounders, were performed to estimate associations between FLG mutation status and chemical concentrations in urine. Results: FLG mutation carriers had 80% (13–180%) higher urinary concentrations of methyl paraben (MeP) and 91% (13–219%) higher concentrations of n-propyl paraben (n-PrP) than controls. For 13 compounds, levels were higher in FLG mutation carriers, although differences were only statistically significant for MeP and n-PrP. Combined statistical analysis of concentrations of all the 18 compounds that were detectable in >10% of subjects, suggested that concentrations were generally higher in mutation carriers (p=0.03). Conclusion: FLG loss-of-function mutation carriers have a higher internal exposure to some non-persistent chemicals, independently of atopic dermatitis. This may be due to increased trans-epidermal absorption and/or higher exposure, and mutation carriers may constitute a group susceptible to increased absorption of chemicals and topical medication. Keywords: Endocrine disrupting chemicals, Phenols, UV filters, Parabens, Filaggrin, Dermal exposure |
| Databáze: | OpenAIRE |
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