Comparison of high-resolution magnetic resonance imaging and micro-computed tomography arthrography for in-vivo assessment of cartilage in non-human primate models
| Autor: | Olivier Beuf, Laurent Mahieu-Williame, T. Chuzel, Denis Grenier, Emmanuel Chereul, Anne-Laure Perrier, F. Taborik, Hugues Contamin, Kevin Tse Ve Koon, L. Magnier |
|---|---|
| Přispěvatelé: | RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme d'Imagerie Multimodale LyonTech (PILoT), CYNBIOSE, Laboratoire Optimisation de la Conception et Ingénierie de l'Environnement (LOCIE), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), VOXCAN, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Tse Ve Koon, Kevin |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
030203 arthritis & rheumatology
medicine.diagnostic_test Computer science Cartilage [INFO.INFO-IM] Computer Science [cs]/Medical Imaging 030209 endocrinology & metabolism Magnetic resonance imaging Context (language use) Image processing Osteoarthritis Knee Joint medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Medical imaging [INFO.INFO-IM]Computer Science [cs]/Medical Imaging Radiology Nuclear Medicine and imaging Tomography ComputingMilieux_MISCELLANEOUS Biomedical engineering |
| Zdroj: | Quantitative Imaging in Medicine and Surgery Quantitative Imaging in Medicine and Surgery, AME Publishing, 2021, 11 (8), pp.3431-3447. ⟨10.21037/qims-20-116⟩ Quantitative Imaging in Medicine and Surgery, 2021, 11 (8), pp.3431-3447. ⟨10.21037/qims-20-116⟩ |
| ISSN: | 2223-4292 2223-4306 |
| DOI: | 10.21037/qims-20-116⟩ |
| Popis: | Background Non-human primate (NHP) could be an interesting model for osteoarthritis (OA) longitudinal studies but standard medical imaging protocols are not able to acquire sufficiently high-resolution images to depict the thinner cartilage (compared to human) in an in vivo context. The aim of this study was thus to develop and validate the acquisition protocols for knee joint examination of NHP using magnetic resonance imaging (MRI) at 1.5 T and X-ray micro-computed tomography arthrography (µCTA). Methods The first phase of the study focused on developing dedicated in vivo HR-MRI and µCTA protocols for simultaneous acquisitions of both knee joints on NHP. For MR, a dedicated two-channel receiver array coil and acquisition sequence were developed on a 1.5 T Siemens Sonata system and tuned to respect safety issues and reasonable examination time. For µCTA, an experimental setup was devised so as to fulfill similar requirements. The two imaging protocols were used during a longitudinal study so as to confirm that repeated injections of loxaglic acid (contrast agent used for µCTA) didn't induce any bias in cartilage assessment and to compare segmentation results from the two modalities. Lateral and medial cartilage tibial plateaus were assessed using a common image processing protocol leading to a 3D estimation of the cartilage thickness. Results From HR-MRI and µCTA images, thickness distributions were extracted allowing for proper evaluation of knee cartilage thickness of the primates. Results obtained in vivo indicated that the µCTA protocol did not induce any bias in the measured cartilage parameters and moreover, segmentation results obtained from the two imaging modalities were consistent. Conclusions MR and µCTA are valuable imaging tools for the morphological evaluation of cartilage in NHP models which in turn can be used for OA studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|