Myocardial metabolic changes during reperfusion of ventricular fibrillation: a 31P nuclear magnetic resonance study in swine
| Autor: | Charles M. Little, Dipti P. Rath, Robert F. Griffith, Mark G. Angelos, Philip D. Beckley |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Magnetic Resonance Spectroscopy Heart disease Phosphocreatine Swine Intracellular pH Ischemia Myocardial Ischemia Myocardial Reperfusion Critical Care and Intensive Care Medicine Great cardiac vein law.invention chemistry.chemical_compound Nuclear magnetic resonance Adenosine Triphosphate Oxygen Consumption law Internal medicine Coronary Circulation medicine Cardiopulmonary bypass Animals Prospective Studies Cardiopulmonary Bypass business.industry Myocardium Blood flow Hydrogen-Ion Concentration medicine.disease chemistry Ventricular fibrillation Ventricular Fibrillation Cardiology Lactates business |
| Zdroj: | Critical care medicine. 23(4) |
| ISSN: | 0090-3493 |
| Popis: | Objective: Myocardial metabolic requirements during reperfusion of ventricular fibrillation are poorly understood. The objective of this study was to determine if controlled reperfusion after a clinically relevant global ischemia period of 10 mins was sufficient to prevent or reverse myocardial ischemia as indicated by changes in myocardial high energy phosphates, myocardial intracellular pH, and great cardiac vein lactate. Design: Prospective laboratory study with controlled reperfusion. Setting: Research laboratory at a university medical center. Subjects: Five swine weighing 19±3 kg. Interventions: Ten minutes of nonperfused ventricular fibrillation followed by reperfusion with cardiopulmonary bypass (flow 30 mL/kg/min) for 50 mins. Measurements and Main Results: Myocardial adenosine triphosphate (ATP), phosphocreatine, and intracellular pH were determined using in vivo 31 P nuclear magnetic resonance. Myocardial blood flow, measured by 15-μ radiolabeled microspheres, was significantly increased above baseline during reperfusion. Phosphocreatine was depleted during the 10 mins of nonperfused ventricular fibrillation, but recovered to 122±18% of baseline with reperfusion and was 112±18% at 60 mins (p |
| Databáze: | OpenAIRE |
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