Trimethyl Chitosan Hydrogel Nanoparticles for Progesterone Delivery in Neurodegenerative Disorders

Autor:	Annarosa Carta, Maria Cristina Cardia, Anna Maria Maccioni, Francesco Lai, Chiara Sinico, Laura Boi, Sara Erbì, Pierluigi Caboni, Maria Cristina Meloni
Rok vydání:	2019
Předmět:	brain Sodium trimethyl chitosan hydrogel nanoparticles Pharmaceutical Science chemistry.chemical_element Nanoparticle 02 engineering and technology progesterone Pharmacology 021001 nanoscience & nanotechnology Neuroprotection Article Polyelectrolyte 03 medical and health sciences 0302 clinical medicine chemistry Pharmacokinetics In vivo Zeta potential 0210 nano-technology 030217 neurology & neurosurgery Ionotropic effect
Zdroj:	Pharmaceutics Volume 11 Issue 12
ISSN:	1999-4923
Popis:	Progesterone is a sex hormone which shows neuroprotective effects in different neurodegenerative disorders, including Parkinson&rsquo s disease, stroke, and Alzheimer&rsquo s disease. However, the pharmacokinetic limitations associated with the peripheral administration of this molecule highlight the need for more efficient delivery approaches to increase brain progesterone levels. Since the nose-to-brain administration of mucoadhesive hydrogel nanoparticles is a non-invasive and convenient strategy for the delivery of therapeutics to the central nervous system, in this work, progesterone-loaded hydrogel nanoparticle formulations have been prepared, characterized, and tested in vivo. Nanoparticles, loaded with different progesterone concentrations, have been obtained by polyelectrolyte complex formation between trimethyl chitosan and sodium alginate, followed by ionotropic gelation with sodium tripolyphosphate as a cross-linking agent. All formulations showed a mean diameter ranging from 200 nm to 236 nm, a polydispersity index smaller than 0.23, and a high progesterone encapsulation efficiency (83&ndash 95%). The zeta potential values were all positive and greater than 28 mV, thus ensuring nanoparticles stability against aggregation phenomena as well as interaction with negative sialic residues of the nasal mucosa. Finally, in vivo studies on Sprague&ndash Dawley male rats demonstrated a 5-fold increase in brain progesterone concentrations compared to basal progesterone level after 30 min of hydrogel nanoparticle inhalation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e0ac42d2e6051badc023eac4ab88f9 https://doi.org/10.3390/pharmaceutics11120657 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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