Experimental high thoracic spinal cord injury impairs the cardiac and cerebrovascular response to orthostatic challenge in rats

Autor:	Jan Elaine Soriano, Erin Erskine, Christopher West, Aaron A. Phillips, Brian Hayes, Ryan E. Rosentreter, Malihe-Sadat Poormasjedi-Meibod, Berkeley A. Scott, David J. Granville, Mary Fossey
Rok vydání:	2021
Předmět:	Male Cardiac function curve Middle Cerebral Artery medicine.medical_specialty Time Factors Physiology Thoracic Vertebrae Ventricular Function Left Hypotension Orthostatic Orthostatic vital signs Physiology (medical) Internal medicine medicine Animals Rats Wistar Spinal cord injury Spinal Cord Injuries Lower Body Negative Pressure business.industry Hemodynamics medicine.disease Adaptation Physiological Disease Models Animal Spinal Cord Cerebrovascular Circulation Cardiology Cardiology and Cardiovascular Medicine business Thoracic spinal cord injury
Zdroj:	American Journal of Physiology-Heart and Circulatory Physiology. 321:H716-H727
ISSN:	1522-1539 0363-6135
Popis:	Spinal cord injury (SCI) impairs the cardiovascular responses to postural challenge, leading to the development of orthostatic hypotension (OH). Here, we apply lower body negative pressure (LBNP) to rodents with high-level SCI to demonstrate the usefulness of LBNP as a model for experimental OH studies, and to explore the effect of simulated OH on cardiovascular and cerebrovascular function following SCI. Male Wistar rats (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e0ab0a0313f1c597eb0169c94b32bf https://doi.org/10.1152/ajpheart.00239.2021 Zobrazit plný text záznamu