Differential Effect of Human Immunodeficiency Virus Infection on the IgA and IgG Antibody Responses to Pneumococcal Vaccine
Autor: | Michel Goldman, F. Mascart-Lemone, Michèle Gerard, Alain Crusiaux, Nathan Clumeck, P Franchioly, A. Lambrechts, Myriam Libin |
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Rok vydání: | 1995 |
Předmět: |
Adult
Male Immunoglobulin A Time Factors Enzyme-Linked Immunosorbent Assay HIV Infections Immunoglobulin G Antigen HIV Seronegativity HIV Seropositivity Humans Immunology and Allergy biology Polysaccharides Bacterial Antibody titer Middle Aged Antibodies Bacterial Pneumococcal polysaccharide vaccine Virology Streptococcus pneumoniae Infectious Diseases Pneumococcal vaccine Immunoglobulin M Antibody Formation Bacterial Vaccines Immunology biology.protein Female Immunization Antibody |
Zdroj: | Journal of Infectious Diseases. 172:1253-1260 |
ISSN: | 1537-6613 0022-1899 |
DOI: | 10.1093/infdis/172.5.1253 |
Popis: | The IgA, IgM, and IgG antibody responses to pneumococcal polysaccharide vaccine were analyzed in 35 asymptomatic or mildly symptomatic human immunodeficiency virus (HIV)-infected patients stratified according to their CD4 cell counts and in 12 healthy controls. Both the antibody titers in serum and saliva and the numbers of circulating antigen-specific antibody-producing cells (Elispot technique) were measured. At the peak of the antibody responses, HIV-infected patients mounted nearly normal IgG responses, while their IgM responses were significantly depressed, regardless of their CD4 cell counts. The IgA antibody response was decreased in patients with < 500 CD4 circulating cells/mm3. Most IgG antibodies belonged to the IgG2 subclass, and most IgA antibodies were dimeric IgA2 in both controls and patients. Anti-capsular pneumococcal polysaccharide IgG titers decreased much more rapidly in HIV-infected patients so that in all groups they were significantly lower than in controls 9 months after vaccination. |
Databáze: | OpenAIRE |
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