The bee venom peptide tertiapin underlines the role of I KACh in acetylcholine-induced atrioventricular blocks
| Autor: | Georges Romey, Cécile Terrenoire, Michel Lazdunski, Milou-Daniel Drici, Sylvie Diochot |
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| Rok vydání: | 2000 |
| Předmět: |
Chronotropic
medicine.medical_specialty Potassium Channels Guinea Pigs Biology Electrocardiography Xenopus laevis chemistry.chemical_compound Heart Conduction System Heart Rate Internal medicine Muscarinic acetylcholine receptor Cardiac conduction Potassium Channel Blockers medicine Animals Drug Interactions Potassium Channels Inwardly Rectifying Pharmacology Tertiapin Heart Muscarinic acetylcholine receptor M2 Acetylcholine Potassium channel Bee Venoms Heart Block Endocrinology G Protein-Coupled Inwardly-Rectifying Potassium Channels chemistry Papers Dromotropic Atrioventricular Node Oocytes Female Rabbits medicine.drug |
| Zdroj: | British Journal of Pharmacology. 131:569-577 |
| ISSN: | 0007-1188 |
| Popis: | Acetylcholine (ACh) is an important neuromodulator of cardiac function that is released upon stimulation of the vagus nerve. Despite numerous reports on activation of IKACh by acetylcholine in cardiomyocytes, it has yet to be demonstrated what role this channel plays in cardiac conduction. We studied the effect of tertiapin, a bee venom peptide blocking IKACh, to evaluate the role of IKACh in Langendorff preparations challenged with ACh. ACh (0.5 μM) reproducibly and reversibly induced complete atrioventricular (AV) blocks in retroperfused guinea-pig isolated hearts (n=12). Tertiapin (10 to 300 nM) dose-dependently and reversibly prevented the AV conduction decrements and the complete blocks in unpaced hearts (n=8, P |
| Databáze: | OpenAIRE |
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