Opposite environmental gating of the experienced utility ('liking') and decision utility ('wanting') of heroin versus cocaine in animals and humans: implications for computational neuroscience
| Autor: | Silvana De Pirro, Daniele Caprioli, Aldo Badiani |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Pleasure media_common.quotation_subject Decision Making Emotions Addiction Opioid Stimulus (physiology) Models Psychological Theoretical and Methodological Perspective Heroin Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Cocaine Dopamine Uptake Inhibitors Reward Utility medicine Animals Humans Computer Simulation media_common Pharmacology Computational model Motivation Computational neuroscience addiction cocaine heroin motivation opioid pleasure psychostimulant reward utility Neurosciences medicine.disease 030227 psychiatry Rats Substance abuse Analgesics Opioid Behavior Addictive Psychostimulant Female Psychology 030217 neurology & neurosurgery Cognitive psychology medicine.drug |
| Zdroj: | Psychopharmacology |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | Background\ud In this paper, we reviewed translational studies concerned with environmental influences on the rewarding effects of heroin versus cocaine in rats and humans with substance use disorder. These studies show that both experienced utility (‘liking’) and decision utility (‘wanting’) of heroin and cocaine shift in opposite directions as a function of the setting in which these drugs were used. Briefly, rats and humans prefer using heroin at home but cocaine outside the home. These findings appear to challenge prevailing theories of drug reward, which focus on the notion of shared substrate of action for drug of abuse, and in particular on their shared ability to facilitate dopaminergic transmission.\ud \ud Aims\ud Thus, in the second part of the paper, we verified whether our findings could be accounted for by available computational models of reward. To account for our findings, a model must include a component that could mediate the substance-specific influence of setting on drug reward\ud \ud Results\ud It appears of the extant models that none is fully compatible with the results of our studies.\ud \ud Conclusions\ud We hope that this paper will serve as stimulus to design computational models more attuned to the complex mechanisms responsible for the rewarding effects of drugs in real-world contexts. |
| Databáze: | OpenAIRE |
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