Phase II trial of vincristine infusion in acute leukemia
| Autor: | Allen R. Chauvenet, Charles L. Spurr, James N. Atkins, Thomas F. Trahey, Don V. Jackson, Richard D. Callahan |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Cancer Research Vincristine Constipation Adolescent medicine.medical_treatment Toxicology Bolus (medicine) hemic and lymphatic diseases Mucositis Medicine Humans Pharmacology (medical) Infusions Parenteral Pharmacology Chemotherapy Acute leukemia Leukemia business.industry Middle Aged medicine.disease Oncology Anesthesia Toxicity Acute Disease Drug Evaluation Female medicine.symptom business medicine.drug |
| Zdroj: | Cancer chemotherapy and pharmacology. 14(1) |
| ISSN: | 0344-5704 |
| Popis: | A phase II trial of prolonged IV infusions of vincristine was conducted in 21 patients with refractory acute leukemia. Patients received 0.25-0.50 mg/m2 by infusion daily for 5 days after an initial 0.5-mg bolus. A partial response was observed in one of two patients with acute lymphoblastic leukemia. Of 14 patients with acute nonlymphoblastic leukemia, a complete response lasting for 2.5 months occurred in one patient and a partial response lasting 1.3 months was observed in a second. No objective responses were noted in five patients with blast crisis of chronic granulocytic leukemia. Nonhematologic toxicity was minimal and, when present, generally consisted of a feeling of weakness; constipation, mucositis, and areflexia were also observed. Hematologic toxicity consisted mainly of mild to moderate reduction of platelets in most patients; marked thrombocytopenia (less than 50,000/mm3) occurred in two patients whose pretreatment platelet count was greater than 100,000/mm3. Although generally well tolerated, prolonged infusion of vincristine appears to have limited activity in the treatment of refractory acute nonlymphoblastic leukemia and blast crisis of chronic granulocytic leukemia; further evaluation is needed in acute lymphoblastic leukemia refractory to conventional bolus injection. |
| Databáze: | OpenAIRE |
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