Growth Hormone-Releasing Peptide 6 Enhances the Healing Process and Improves the Esthetic Outcome of the Wounds
| Autor: | Ariana García Ojalvo, Ana Janet Mir Benítez, Maday Fernández Mayola, Yilian Bermúdez Alvarez, Ana Aguilera Barreto, Yssel Mendoza Marí, Jorge Berlanga Acosta |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Article Subject CD36 lcsh:Surgery Reversion Scars Stimulation Pharmacology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Receptor biology business.industry Granulation tissue Histology lcsh:RD1-811 030104 developmental biology medicine.anatomical_structure Pharmacodynamics biology.protein medicine.symptom business Research Article |
| Zdroj: | Plastic Surgery International Plastic Surgery International, Vol 2016 (2016) |
| ISSN: | 2090-1461 |
| DOI: | 10.1155/2016/4361702 |
| Popis: | In addition to its cytoprotective effects, growth hormone-releasing peptide 6 (GHRP-6) proved to reduce liver fibrotic induration. CD36 as one of the GHRP-6 receptors appears abundantly represented in cutaneous wounds granulation tissue. The healing response in a scenario of CD36 agonistic stimulation had not been previously investigated. Excisional full-thickness wounds (6 mmØ) were created in the dorsum of Wistar rats and topically treated twice a day for 5 days. The universal model of rabbit’s ears hypertrophic scars was implemented and the animals were treated daily for 30 days. Treatments for both species were based on a CMC jelly composition containing GHRP-6 400 μg/mL. Wounds response characterization included closure dynamic, RT-PCR transcriptional profile, histology, and histomorphometric procedures. The rats experiment indicated that GHRP-6 pharmacodynamics involves attenuation of immunoinflammatory mediators, their effector cells, and the reduction of the expression of fibrotic cytokines. Importantly, in the hypertrophic scars rabbit’s model, GHRP-6 intervention dramatically reduced the onset of exuberant scars by activating PPARγ and reducing the expression of fibrogenic cytokines. GHRP-6 showed no effect on the reversion of consolidated lesions. This evidence supports the notion that CD36 is an active and pharmacologically approachable receptor to attenuate wound inflammation and accelerate its closure so as to improve wound esthetic. |
| Databáze: | OpenAIRE |
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