Clinical associations between metabolic syndrome and the development of microalbuminuria in Korean men
| Autor: | Hyejin Chun, Jae-Hong Ryoo, Sung Keun Park, Joong Myung Choi, Chang-Mo Oh, Min Gi Kim, Taeg Su Ko, Ho Cheol Shin, Eunkyung Suh, Hong Soo Lee |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism urologic and male genital diseases Cohort Studies Endocrinology Asian People Risk Factors Internal medicine Republic of Korea Diabetes Mellitus Internal Medicine medicine Albuminuria Humans Risk factor Prospective cohort study Proportional Hazards Models Metabolic Syndrome Proportional hazards model business.industry Incidence Hazard ratio nutritional and metabolic diseases General Medicine Middle Aged medicine.disease female genital diseases and pregnancy complications Confidence interval Microalbuminuria Metabolic syndrome business Body mass index |
| Zdroj: | Diabetes Research and Clinical Practice. 107:407-414 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2014.12.005 |
| Popis: | Aims There have been several studies on the association between metabolic syndrome (MetS) and microalbuminuria. However, none has examined whether MetS is associated with the prospective development of microalbuminuria. Accordingly, we performed a prospective study to evaluate the longitudinal effects of baseline number of MetS traits on the development of microalbuminuria in Korean men. Methods 1649 Korean men without microalbuminuria in 2005 were included and followed prospectively until 2010 with the endpoint being the development of microalbuminuria. MetS was defined according to the joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Microalbuminuria was evaluated by urine albumin creatinine ratio (UACR). Risk estimations for development of microalbuminuria were analyzed according to the number of MetS traits using multivariate adjusted Cox proportional hazards model. Results During 5611.8 person-years of follow-up (median 3.40 ± 1.46 years), microalbuminuria developed in 91 (5.5%) participants between 2006 and 2010. After adjusting for multiple covariates, the hazard ratios (95% confidence interval) for development of microalbuminuria comparing 1, 2 and 3–5 MetS traits vs 0 were 2.57 (0.97–6.82), 2.94 (1.09–7.98) and 3.85 (1.37–10.86), respectively. Conclusions The number of MetS traits independently associated with the future development of microalbuminuria during the 5-year follow-up period, and MetS per se was an independent risk factor for microalbuminuria. |
| Databáze: | OpenAIRE |
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