Seasonal Variations and Associated Factors of Gout Attacks: a Prospective Multicenter Study in Korea
| Autor: | Ki Won Moon, Mi Ryoung Seo, Ju-Yang Jung, Chang Hee Suh, Seung Jae Hong, Han Joo Baek, Sang Tae Choi, Hyo Jin Choi, Eun Kyoung Park, You Jung Ha, Hyun Ok Kim, Seung-Geun Lee, Hyoun-Ah Kim, Jisoo Lee, In Je Kim, Yeon Ah Lee, Jung Soo Song |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Gout 03 medical and health sciences Young Adult 0302 clinical medicine Immunology Allergic Disorders & Rheumatology Risk Factors Internal medicine Republic of Korea medicine Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Aged business.industry Incidence (epidemiology) Diurnal temperature variation Temperature Humidity General Medicine Seasonality Middle Aged medicine.disease Rheumatology Cohort Original Article Female Season Seasons business Alcohol Body mass index Follow-Up Studies |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | Background We purposed to evaluate the seasonality and associated factors of the incidence of gout attacks in Korea. Methods We prospectively enrolled patients with gout attacks who were treated at nine rheumatology clinics between January 2015 and July 2018 and followed them for 1-year. Demographic data, clinical and laboratory features, and meteorological data including seasonality were collected. Results Two hundred-five patients (men, 94.1%) were enrolled. The proportion of patients with initial gout attacks was 46.8% (n = 96). The median age, body mass index, attack duration, and serum uric acid level at enrollment were 50.0 years, 25.4, 5.0 days, and 7.4 mg/dL, respectively. Gout attacks were most common during spring (43.4%, P < 0.001) and in March (23.4%, P < 0.001). A similar pattern of seasonality was observed in the group with initial gout attacks. Alcohol was the most common provoking factor (39.0%), particularly during summer (50.0%). The median diurnal temperature change on the day of the attack was highest in the spring (9.8°C), followed by winter (9.3°C), fall (8.6°C), and summer (7.1°C) (P = 0.027). The median change in humidity between the 2 consecutive days (the day before and the day of the attack) was significantly different among the seasons (3.0%, spring; 0.3%, summer; −0.9%, fall; −1.2%, winter; P = 0.015). One hundred twenty-five (61%) patients completed 1-year follow-up (51% in the initial attack group). During the follow-up period, 64 gout flares developed (21 in the initial attack group). No significant seasonal variation in the follow-up flares was found. Conclusion In this prospective study, the most common season and month of gout attacks in Korea are spring and March, respectively. Alcohol is the most common provoking factor, particularly during summer. Diurnal temperature changes on the day of the attack and humidity changes from the day before the attack to the day of the attack are associated with gout attack in our cohort. Graphical Abstract |
| Databáze: | OpenAIRE |
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