Biocompatible Supramolecular Catalytic One-Dimensional Nanofibers For Efficient Labeling Of Live Cells
| Autor: | Gulcihan Gulseren, Mustafa O. Guler, Mohammad Aref Khalily, Ayse B. Tekinay |
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| Přispěvatelé: | Güler, Mustafa O. |
| Rok vydání: | 2015 |
| Předmět: |
Models
Molecular Cell Survival Cytotoxicity Biomedical Engineering Supramolecular chemistry Nanofibers Pharmaceutical Science Bioengineering Peptide Nanotechnology Article Catalysis Coordination Complexes Humans Cycloaddition Alkyne Fluorescent Dyes Pharmacology chemistry.chemical_classification Microscopy Confocal Staining and Labeling Click chemistry Biomolecule Organic Chemistry Copper ion Nanofiber Flow Cytometry chemistry Azide Nanocatalyst MCF-7 Cells Click Chemistry Bioorthogonal chemistry Peptides Amphophile Chemical reaction Controlled study Cell function Copper Biotechnology Cell labeling |
| Zdroj: | Bioconjugate Chemistry |
| Popis: | Understanding complex cellular functions requires study and tracking of biomolecules such as proteins, glycans, and lipids in their natural environment. Herein, we report the first supramolecular nanocatalyst for bioorthogonal click reaction to label live cells. This biocompatible and biodegradable nanocatalyst was formed by self-assembled peptide nanofibers complexed with copper ions. The supramolecular nanocatalyst enhanced azide-alkyne cycloaddition reaction rate under physiological conditions and was shown to be useful for efficient bioorthogonal labeling of live cells. |
| Databáze: | OpenAIRE |
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