Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis
| Autor: | Dan F. Young, Richard E. Randall, Marian J. Killip, B. Precious, Steve Goodbourn |
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| Přispěvatelé: | The Wellcome Trust, University of St Andrews. School of Biology, University of St Andrews. Biomedical Sciences Research Complex |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Transcriptional Activation
RNA viruses Paramyxoviridae viruses Mumps virus Virus Replication medicine.disease_cause Defective virus Cell Line Viral Proteins Interferon Virology medicine Animals Humans Rubulavirus Promoter Regions Genetic QR355 biology Animal Defective Viruses Interferon-beta biology.organism_classification Standard Sendai virus Viral replication Cell culture QR355 Virology medicine.drug |
| Zdroj: | The Journal of General Virology |
| ISSN: | 0022-1317 |
| Popis: | Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are not normally generated during virus replication, but are associated instead with the presence of defective interfering (DI) viruses. We demonstrate here that DIs of paramyxoviruses, including parainfluenza virus 5, mumps virus and Sendai virus, can activate the IFN-induction cascade and the IFN-beta promoter in the absence of virus protein synthesis. As virus protein synthesis is an absolute requirement for paramyxovirus genome replication, our results indicate that these DI viruses do not require replication to activate the IFN-induction cascade. Publisher PDF |
| Databáze: | OpenAIRE |
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