Combined donor-recipient genotypes of leptin receptor and adiponectin gene polymorphisms affect the incidence of complications after renal transplantation
| Autor: | Luz M. González, Sonia Mota-Zamorano, Guadalupe García-Pino, Enrique Luna, Guillermo Gervasini |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
CI
95% confidence interval Leptin Graft loss medicine.medical_specialty Renal function Lower risk Gastroenterology DGF delayed graft function DNA deoxyribonucleic acid Endocrinology Internal medicine Genotype medicine Genetics Molecular Biology Gene lcsh:QH301-705.5 lcsh:R5-920 ADIPOQ adiponectin gene Leptin receptor Adiponectin business.industry CKD chronic kidney disease Delayed graft function OR odds ratio Transplantation Renal transplant lcsh:Biology (General) eGFR glomerular filtration rate LEPR leptin receptor gene SNP single-nucleotide polymorphism Graft function business lcsh:Medicine (General) Donor Research Paper |
| Zdroj: | Molecular Genetics and Metabolism Reports, Vol 25, Iss, Pp 100648-(2020) Molecular Genetics and Metabolism Reports |
| ISSN: | 2214-4269 |
| Popis: | Background We aimed to examine whether combined donor/recipient variants in the leptin receptor (LEPR) and adiponectin (ADIPOQ) genes may affect outcomes in renal transplantation. Methods A total of 233 donors and their corresponding 307 recipients were genotyped for LEPR rs1805094, rs1137100 and rs1137101, and ADIPOQ rs1501299 and rs224176. Combined donor/recipient genetic scores were created to investigate associations with delayed graft function (DGF), graft loss and estimated glomerular filtration rate (eGFR). Results Recipients whose donors carried variant alleles of LEPR rs1137100 and rs1137101 had lower risk of DGF [OR = 0.48 (0.24–0.97), p = 0.040] and [OR = 0.47 (0.23–0.95), p = 0.035], respectively. In addition, rs1137101 also showed an inverse association with lower incidence of graft loss [OR = 0.44 (0.31–0.97), p = 0.040]. The analysis of genetic scores of donor/recipients showed that again rs1137101 was inversely associated with both outcomes: OR = 0.46 (0.23–0.92), p = 0.029 and OR = 0.45 (0.11–0.81), p = 0.009, respectively. With regard to graft function, the T-allele of ADIPOQ rs1501299 in the donor was related to higher eGFR values (75.26 ± 29.01 vs. 67.34 ± 25.39 ml/min for wild-type grafts, p = 0.012). Higher combined genetic scores in this same polymorphism were also associated with better function (78.33 ± 31.87 vs. 68.25 ± 24.32 ml/min, p = 0.018). Finally, eGFR values were similar between paired kidneys but they were different when comparing grafts with or without the rs1501299 T-variant (77.87 ± 26.50 vs. 69.27 ± 26.73 ml/min, p = 0.016). Conclusions Our study has shown for the first time to our knowledge that variants in LEPR and ADIPOQ genes of the donors and/or their combination with those in the recipients may affect the outcome of renal transplantation. |
| Databáze: | OpenAIRE |
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