Reduced Smooth Muscle Contractile Capacity Facilitates Maladaptive Arterial Remodeling
| Autor: | Jay D. Humphrey, JohnF Eberth |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Marfan syndrome
medicine.medical_specialty business.industry Carotid Artery Common Biomedical Engineering Matrix (biology) medicine.disease Muscle Smooth Vascular Mice Smooth muscle In vivo Physiology (medical) Vasoactive Internal medicine Hypertension medicine Cardiology Shear stress Central Artery Animals Stress Mechanical business Technical Briefs Homeostasis Muscle Contraction |
| Zdroj: | J Biomech Eng |
| ISSN: | 1528-8951 |
| Popis: | Albeit seldom considered explicitly, the vasoactive state of a central artery can contribute to luminal control and thereby affect the in vivo values of flow-induced wall shear stress and pressure-induced intramural stress, which in turn are strong determinants of wall growth and remodeling. Here, we test the hypothesis that diminished vasoactive capacity compromises effective mechano-adaptations of central arteries. Toward this end, we use consistent methods to re-interpret published data on common carotid artery remodeling in a nonpharmacologic mouse model of induced hypertension and a model of connective tissue disorder that results in Marfan syndrome. The mice have identical genetic backgrounds and, in both cases, the data are consistent with the hypothesis considered. In particular, carotid arteries with strong (normal) vasoactive capacity tend to maintain wall thickness and in vivo axial stretch closer to homeostatic, thus resulting in passive circumferential wall stress and energy storage close to normal. We conclude that effective vasoactivity helps to control the biomechanical state in which the cells and matrix turnover, thus helping to delineate mechano-adaptive from maladaptive remodeling. Future analyses of experimental data and computational models of growth and remodeling should account for this strong coupling between smooth muscle contractile capacity and central arterial remodeling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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