Nongestational choriocarcinoma in the postpartum period: a case report
| Autor: | Ishwad Cs, Surti U, Neyssa Marina, O'Hanlan Ka, Kaveri Suryanarayan, Nowels K, Letourneau D |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Pathology Adolescent media_common.quotation_subject Polymerase Chain Reaction law.invention Chorioepithelioma law Medicine Humans Choriocarcinoma Polymerase chain reaction media_common Daughter business.industry Obstetrics Postpartum Period Hematology DNA Neoplasm medicine.disease Prognosis Oncology Pediatrics Perinatology and Child Health Uterine Neoplasms Etiology Gestation Microsatellite Female business Postpartum period |
| Zdroj: | Journal of pediatric hematology/oncology. 20(2) |
| ISSN: | 1077-4114 |
| Popis: | Purpose: To determine the tissue of origin (gestational versus nongestational) of an extensive metastatic choriocarcinoma in an 18-year-old woman to determine prognosis and treatment. Methods: DNA microsatellite polymorphisms after polymerase chain reaction (PCR) amplification of the tumor tissue and blood from the patient, husband, and daughter were used to determine the tissue of origin. Results: Molecular analyses revealed that the tumor shared the genetic features of only the patient. She responded well to multiagent chemotherapy. Conclusions: Molecular analysis is a useful tool to determine whether a choriocarcinoma occurring in a female patient of child-bearing age is gestational or nongestational when clinical findings are not clearly indicative of the primary. |
| Databáze: | OpenAIRE |
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