Short communication: The effect of calcium supplementation at calving on neutrophil function
| Autor: | Elizabeth L. Scholtz, Dorothee Bienzle, Stephen J. LeBlanc, Todd F. Duffield, Cynthia L. Miltenburg |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Canada medicine.medical_specialty Neutrophils Phagocytosis chemistry.chemical_element Ice calving Calcium Placebo 03 medical and health sciences Immune system Pregnancy Internal medicine Lactation Genetics Calcium glucoheptonate medicine Animals Chemistry Quebec 0402 animal and dairy science 04 agricultural and veterinary sciences 040201 dairy & animal science Respiratory burst Milk 030104 developmental biology medicine.anatomical_structure Endocrinology Cattle Female Animal Science and Zoology Food Science medicine.drug |
| Zdroj: | Journal of Dairy Science. 101:9505-9509 |
| ISSN: | 0022-0302 |
| Popis: | Low total blood calcium concentration after calving has been demonstrated to be a risk factor for reduced neutrophil function. The objective of this study was to evaluate whether administration of an injectable calcium supplement product soon after calving increased neutrophil oxidative burst or phagocytosis capacity. Cows (n = 27) from 4 farms were blocked by parity and randomly assigned to receive either calcium gluconate (35% wt/vol) in combination with calcium glucoheptonate (10% wt/vol; Theracalcium, Vétoquinol Canada Inc., Lavaltrie, Quebec, Canada) or a placebo within 12 h after calving and again 24 h later. Each dose of 120 mL was injected subcutaneously over 2 sites. Total serum calcium concentration, neutrophil oxidative burst, and neutrophil phagocytosis capacity were measured from coccygeal blood samples before (time 0) and 72 h after first treatment. There was no difference between treatment groups in lactation number, total calcium concentration, oxidative burst, or phagocytosis at time of enrollment. There was no effect of treatment on oxidative burst or phagocytosis by neutrophils. This preliminary study does not support an effect of supplemental calcium to improve neutrophil oxidative burst or phagocytosis capacity of low-parity parturient cows. |
| Databáze: | OpenAIRE |
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