Mechanisms of Transcription Elongation Factor DSIF (Spt4-Spt5)
| Autor: | Tim-Michael Decker |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Chromosomal Proteins
Non-Histone RNA polymerase II 03 medical and health sciences Transcription Elongation Factor SPT5 0302 clinical medicine Structural Biology Transcription (biology) Yeasts Nucleosome Animals Humans Enhancer Promoter Regions Genetic Molecular Biology Transcription factor 030304 developmental biology Regulation of gene expression 0303 health sciences biology DSIF Cell biology Nucleosomes Repressor Proteins Enhancer Elements Genetic Gene Expression Regulation Multiprotein Complexes biology.protein RNA Polymerase II Transcriptional Elongation Factors 030217 neurology & neurosurgery Protein Binding |
| Zdroj: | Journal of molecular biology. 433(14) |
| ISSN: | 1089-8638 |
| Popis: | The transcription elongation factor Spt5 is conserved from bacteria to humans. In eukaryotes, Spt5 forms a complex with Spt4 and regulates processive transcription elongation. Recent studies on transcription elongation suggest different mechanistic roles in yeast versus mammals. Higher eukaryotes utilize Spt4-Spt5 (DSIF) to regulate promoter-proximal pausing, a transcription-regulatory mechanism that connects initiation to productive elongation. DSIF is a versatile transcription factor and has been implicated in both gene-specific regulation and transcription through nucleosomes. Future studies will further elucidate the role of DSIF in transcriptional dynamics and disentangle its inhibitory and enhancing activities in transcription. |
| Databáze: | OpenAIRE |
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