Histomorphometric comparison of different concentrations of recombinant human bone morphogenetic protein with allogeneic bone compared to the use of 100% mineralized cancellous bone allograft in maxillary sinus grafting
| Autor: | Sang-Choon Cho, Timothy G. Bromage, Robert Schoor, Robert J. Norman, Stuart J. Froum, Scott H Froum, Dennis P. Tarnow, Ismael Khouly, Patricia Corby, Edwin S. Rosenberg, Stephen S. Wallace |
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| Rok vydání: | 2013 |
| Předmět: |
Bone Transplantation
Maxillary sinus Dose-Response Relationship Drug business.industry Dentistry Antibiotic Prophylaxis Maxillary Sinus Bone morphogenetic protein Grafting Recombinant Proteins law.invention Transplantation medicine.anatomical_structure law Bone Morphogenetic Proteins medicine Recombinant DNA Periodontics Humans Transplantation Homologous Oral Surgery business Prospective cohort study Cancellous bone Sinus (anatomy) |
| Zdroj: | The International journal of periodonticsrestorative dentistry. 33(6) |
| ISSN: | 1945-3388 |
| Popis: | The purpose of this study was to histomorphometrically evaluate the percentage of vital bone after grafting of maxillary sinuses using two different concentrations of recombinant human bone morphogenetic protein/acellular collagen sponge (rhBMP-2/ACS) combined with mineralized cancellous bone allograft (MCBA) and to compare the results to a control sinus grafted with MCBA only. Thirty-six sinuses in 18 patients had two of three of the graft combinations including: (1) control, MCBA only; (2) test one, MCBA + 5.6 mL of rhBMP-2/ACS (containing 8.4 mg of rhBMP-2); or (3) test two, MCBA + 2.8 mL of rhBMP-2/ACS (containing 4.2 mg of rhBMP-2). Histologic cores were taken 6 to 9 month following sinus augmentation. The results showed no statistically significant differences in vital bone between the two test groups compared to the control sinus group treated with MCBA alone. Future studies involving more cases and evaluating survival of implants placed in these augmented sinuses are needed to verify the results of this randomized prospective study. |
| Databáze: | OpenAIRE |
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