Nickel-Catalyzed Conversion of Enol Triflates into Alkenyl Halides
| Autor: | Kelsey E. Poremba, Alex Shimozono, Julie L. Hofstra, Sarah E. Reisman |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Reaction mechanism 010405 organic chemistry Alkene Halogenation chemistry.chemical_element Halide General Medicine General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Enol Catalysis Article 0104 chemical sciences chemistry.chemical_compound Nickel chemistry Pyridine |
| Zdroj: | Angew Chem Int Ed Engl |
| ISSN: | 1521-3773 |
| Popis: | A Ni‐catalyzed halogenation of enol triflates was developed and it enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench‐stable Ni(OAc)_2⋅4 H_2O as a precatalyst and proceeds at room temperature in the presence of sub‐stoichiometric Zn and either 1,5‐cyclooctadiene or 4‐(N,N‐dimethylamino)pyridine. |
| Databáze: | OpenAIRE |
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