Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging
| Autor: | Søren Lundbye-Christensen, Ajit Shankaranarayanan, Elna-Marie Larsson, Finn Taagehøj Jensen, David C. Alsop, Hanna Järnum, Ernst-Torben Wilhelm Fründ, Elena Steffensen, Carsten Wiberg Simonsen, Linda Knutsson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Perfusion Imaging Spin labelling Perfusion scanning Contrast imaging Nerve Fibers Myelinated Article Young Adult Nuclear magnetic resonance Imaging Three-Dimensional Cerebellum Medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Neuroradiology Aged Aged 80 and over Nerve Fibers Unmyelinated medicine.diagnostic_test business.industry Brain Neoplasms Brain Magnetic resonance imaging Site-directed spin labeling Middle Aged Magnetic Resonance Imaging body regions Cerebrovascular Circulation Female Neurology (clinical) Cardiology and Cardiovascular Medicine business Artifacts Perfusion Dynamic susceptibility |
| Zdroj: | Järnum, H, Steffensen, E, Knutsson, L, Fründ, E-T, Simonsen, C W, Lundbye-Christensen, S, Shankaranarayanan, A, Alsop, D C, Jensen, F T & Larsson, E-M 2010, ' Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging ', Neuroradiology, vol. 52, no. 4, pp. 307-17 . https://doi.org/10.1007/s00234-009-0616-6 |
| DOI: | 10.1007/s00234-009-0616-6 |
| Popis: | Udgivelsesdato: 2010 INTRODUCTION: The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. METHODS: A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no susceptibility artefacts and 2 = extensive susceptibility artefacts (maximum diameter > 2 cm)). A quantitative analysis was performed with normalised tumour blood flow values (ASL nTBF, DSC nTBF): mean value for region of interest (ROI) in an area with maximum signal enhancement/the mean value for ROIs in cerebellum. RESULTS: There was no difference in total visual score for signal enhancement between PC ASL and DSC relative cerebral blood flow (p = 0.12). ASL had a lower susceptibility-artefact score than DSC-MRI (p = 0.03). There was good correlation between DSC nTBF and ASL nTBF values with a correlation coefficient of 0.82. CONCLUSION: PC ASL is an alternative to DSC-MRI for the evaluation of perfusion in brain tumours. The method has fewer susceptibility artefacts than DSC-MRI and can be used in patients with renal failure because no contrast injection is needed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|