Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in gerbils
| Autor: | Katalin Sas, Gabor Gigler, László Vécsei, Laszlo G. Harsing, Gábor Szénási, György Lévay, József Toldi, Annamária Simó |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Ischemia Stimulation Motor Activity Neuroprotection Body Temperature Brain Ischemia Brain ischemia chemistry.chemical_compound Mice Kynurenic acid Species Specificity Memory Internal medicine medicine.artery medicine Electrocoagulation Animals Amino Acids Maze Learning Kynurenine Pharmacology Behavior Animal Dose-Response Relationship Drug business.industry Brain medicine.disease Disease Models Animal Endocrinology Neuroprotective Agents chemistry Blood-Brain Barrier Anesthesia Middle cerebral artery NMDA receptor business Gerbillinae |
| Zdroj: | European journal of pharmacology. 564(1-3) |
| ISSN: | 0014-2999 |
| Popis: | Excessive stimulation of N-methyl-D-aspartate (NMDA) receptors during ischemia contributes to apoptotic and excitotoxic nerve cell death. Kynurenic acid is a selective antagonist at the glycine co-agonist site of the NMDA receptor complex at low concentration, and it is a broad-spectrum excitatory amino acid receptor blocker at high concentration. Kynurenic acid provides neuroprotection in animal models of cerebral ischemia only at very high doses as it hardly crosses the blood-brain barrier. The neuroprotective effect of L-kynurenine sulfate, a precursor of kynurenic acid, was therefore studied because L-kynurenine readily crosses the blood-brain barrier. L-kynurenine sulfate was administered 15 min before permanent focal cerebral ischemia produced by electrocoagulation of the distal middle cerebral artery in mice. L-kynurenine sulfate induced a small decrease in the surface area of the brain infarction (10%, P |
| Databáze: | OpenAIRE |
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