A comparison of the side effects of prilocaine with felypressin and lignocaine with adrenaline in large loop excision of the transformation zone of the cervix: results of a randomised trial
| Autor: | H. Tucker, J. Foden Shroff, Peter W. Jones, R. E. J. Howells, K. K. Dhar, C. W. E. Redman, J. Millinship |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Lidocaine Epinephrine medicine.drug_class Uterine Cervical Neoplasms Prilocaine chemistry.chemical_compound Blood loss medicine Humans Vasoconstrictor Agents Loop excision Prospective Studies Anesthetics Local Cervix Felypressin business.industry Local anesthetic Obstetrics and Gynecology Middle Aged Anesthetics Combined Surgery medicine.anatomical_structure chemistry Colposcopy Anesthesia Female business Transformation zone medicine.drug |
| Zdroj: | BJOG : an international journal of obstetrics and gynaecology. 107(1) |
| ISSN: | 1470-0328 |
| Popis: | Objective To test the hypothesis that prilocaine with felypressin causes fewer side effects than lignocaine with adrenaline when performing large loop excision of the transformation zone of the cervix. Design Randomised trial. Setting Colposcopy clinic in a large district general hospital. Participants Two hundred consecutive women undergoing large loop excision of the transformation zone of the cervix. Methods Two different local anaesthetic combinations (prilocaine with felypressin and lignocaine with adrenaline) were compared in women undergoing large loop excision of the transformation zone. Prospective collection of clinical and treatment data was undertaken with scoring using an ordinal scale of pain experienced by the women during the procedure. Peri-operative blood loss and any side effects were also recorded. Main outcome measures Side effects associated with the local anaesthetic agents. Results Lignocaine with adrenaline resulted in less blood loss (P= 0.006) but was more likely to cause side effects, such as feeling faint (P= 0.017) and shaking (P < 0.001). Conclusion Prilocaine with felypressin causes fewer side effects than lignocaine with adrenaline and is therefore the preferred local anaesthetic combination for large loop excision of the transformation zone. |
| Databáze: | OpenAIRE |
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