The role of lipids in α-synuclein misfolding and neurotoxicity
| Autor: | Victoria A. Lawson, David Finkelstein, Cathryn L Ugalde, Andrew F. Hill |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Central Nervous System Amyloid Biology Biochemistry Protein Aggregation Pathological 03 medical and health sciences chemistry.chemical_compound medicine Humans Proteostasis Deficiencies Molecular Biology Alpha-synuclein Synucleinopathies 030102 biochemistry & molecular biology Lewy body Mechanism (biology) JBC Reviews Neurodegeneration Neurotoxicity Cell Biology medicine.disease Lipids 030104 developmental biology chemistry Fatty Acids Unsaturated alpha-Synuclein Neuroscience Intracellular |
| Popis: | The misfolding and aggregation of α-synuclein (αsyn) in the central nervous system is associated with a group of neurodegenerative disorders referred to as the synucleinopathies. In addition to being a pathological hallmark of disease, it is now well-established that upon misfolding, αsyn acquires pathogenic properties, such as neurotoxicity, that can contribute to disease development. The mechanisms that produce αsyn misfolding and the molecular events underlying the neuronal damage caused by these misfolded species are not well-defined. A consistent observation that may be relevant to αsyn's pathogenicity is its ability to associate with lipids. This appears important not only to how αsyn aggregates, but also to the mechanism by which the misfolded protein causes intracellular damage. This review discusses the current literature reporting a role of lipids in αsyn misfolding and neurotoxicity in various synucleinopathy disorders and provides an overview of current methods to assess protein misfolding and pathogenicity both in vitro and in vivo. |
| Databáze: | OpenAIRE |
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