Structural and functional characteristics of oestrogen receptor β splice variants: Implications for the ageing brain
| Autor: | AnnaDorothea Asimes, Wilson C. J. Chung, Chun K. Kim, Audrey Torcaso, Toni R. Pak |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gene isoform medicine.medical_specialty Aging Endocrinology Diabetes and Metabolism Context (language use) Biology Article 03 medical and health sciences Cellular and Molecular Neuroscience Endocrinology Internal medicine medicine Animals Estrogen Receptor beta Humans Protein Isoforms splice Estrogen receptor beta Endocrine and Autonomic Systems Alternative splicing Brain Estrogens Alternative Splicing 030104 developmental biology Nuclear receptor RNA splicing Hormone |
| Zdroj: | Journal of neuroendocrinology. 30(2) |
| ISSN: | 1365-2826 |
| Popis: | Estrogen receptor beta (ERβ) is a multifunctional nuclear receptor that mediates the actions of estrogenic compounds. Despite its well defined role in mediating the actions of estrogens, a substantial body of evidence demonstrates that ERβ has broad range of physiological functions that are independent of those normally attributed to estrogen signaling. These functions can, in part, be achieved by the activity of several alternatively spliced isoforms that have been identified for ERβ. This short review will describe structural differences between the ERβ splice variants that are known to be translated into proteins. Moreover, we discuss how these alternative structures contribute to functional differences in the context of both healthy and pathological conditions. This review also describes the principal factors that regulate alternative RNA splicing. The alternatively spliced isoforms of ERβ are differentially expressed according to brain region, age, and hormonal milieu underscoring the likelihood that there are precise cell-specific mechanisms that regulate ERβ alternative splicing. However, despite these correlative data, the molecular factors regulating alternative ERβ splicing in the brain remain unknown. Here, we review the basic mechanisms that regulate alternative RNA splicing and use that framework to make logical predictions about ERβ alternative splicing in the brain. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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