Animal mesenchymal stem cell research in cartilage regenerative medicine – a review
| Autor: | Kuldeep Dhama, Mudasir Bashir Gugjoo, Mohmmad Abrar Gayas, Raja Aijaz Ahmad, Amarpal, Mujeeb-Ur Rehman Fazili |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cartilage
Articular 040301 veterinary sciences Mesenchymal Stem Cell Transplantation Regenerative Medicine Regenerative medicine 0403 veterinary science Dogs Risk Factors chondrogenesis Articular cartilage repair Medicine Horses clinical studies Induced pluripotent stem cell preclinical studies mesenchymal stem cell cartilage regenerative medicine lcsh:Veterinary medicine General Veterinary business.industry Cartilage Goats Mesenchymal stem cell 0402 animal and dairy science Mesenchymal Stem Cells 04 agricultural and veterinary sciences Chondrogenesis 040201 dairy & animal science Embryonic stem cell Cell biology animals medicine.anatomical_structure Treatment Outcome lcsh:SF600-1100 Stem cell business |
| Zdroj: | Veterinary Quarterly, Vol 39, Iss 1, Pp 95-120 (2019) |
| ISSN: | 1875-5941 0165-2176 |
| Popis: | Healing of articular cartilage is a major clinical challenge as it also lacks a direct vasculature and nerves, and carries a limited number of resident chondrocytes that do not proliferate easily. Damaged articular cartilages are usually replaced by fibrocartilages, which are mechanically and structurally weaker and less resilient. Regenerative medicine involving stem cells is considered to have a definitive potential to overcome the limitations associated with the currently available surgical methods of cartilage repair. Among various stem cell types, mesenchymal stem cells (MSCs) are preferred for clinical applications. These cells can be readily derived from various sources and have the ability to trans-differentiate into various tissue-specific cells, including those of the cartilage by the process of chondrogenesis. Compared to embryonic or induced pluripotent stem cells (iPSCs), no ethical or teratogenic issues are associated with MSCs. These stem cells are being extensively evaluated for the treatment of joint affections and the results appear promising. Unlike human medicine, in veterinary medicine, the literature on stem cell research for cartilage regeneration is limited. This review, therefore, aims to comprehensively discuss the available literature and pinpoint the achievements and limitations associated with the use of MSCs for articular cartilage repair in animal species. |
| Databáze: | OpenAIRE |
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