Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats
| Autor: | Hala Salah Abdel-Kawy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Liver toxicity Health Toxicology and Mutagenesis Adrenergic beta-Antagonists Propranolol 010501 environmental sciences Liver Cirrhosis Experimental Toxicology 01 natural sciences Gastroenterology 03 medical and health sciences 0302 clinical medicine Malondialdehyde Internal medicine Hepatic Stellate Cells medicine Animals Aspartate Aminotransferases Rats Wistar Carbon Tetrachloride Carvedilol Acetaminophen 0105 earth and related environmental sciences Pharmacology Chemical Health and Safety Tumor Necrosis Factor-alpha business.industry Public Health Environmental and Occupational Health Alanine Transaminase General Medicine Glutathione Gastroesophageal varices Oxidative Stress Liver Chemical and Drug Induced Liver Injury Chronic Chemical and Drug Induced Liver Injury business Varices Biomarkers 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Drug and Chemical Toxicology. 44:101-111 |
| ISSN: | 1525-6014 0148-0545 |
| DOI: | 10.1080/01480545.2019.1576718 |
| Popis: | Non-selective β-blockers have largely been used for prophylaxis of bleeding from gastroesophageal varices, but their hepatic effects and their influence on the development of varices has yet to be clarified. This study examined whether carvedilol would reduce acute and chronic liver injury in rats in comparison to propranolol. Experiment (1) Investigated the effects of carvedilol (1.2 mg/kg) and propranolol (4.0 mg/kg) administered daily for 7 days by gavage on paracetamol (1500 mg/kg i.p.) -induced acute liver injury in rats. Experiment (2) Investigated the effects of carvedilol (1.2 mg/kg) and propranolol (4.0 mg/kg) by gavage daily for 8 weeks on CCl |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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