An Unusual Pathway of Mitoptosis Found in Ehrlich Carcinoma Cells
| Autor: | Arkadiy Reunov, E. S. Menchinskaya, Yu. A. Reunova, Evgenia Pimenova, Dmitry L. Aminin |
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| Rok vydání: | 2020 |
| Předmět: |
Programmed cell death
Necrosis Cell Apoptosis Mitochondrion General Biochemistry Genetics and Molecular Biology Ehrlich ascites carcinoma Cell membrane Mice medicine Animals Humans Carcinoma Ehrlich Tumor General Immunology and Microbiology Chemistry Cell Membrane General Medicine Cell biology Mitochondria medicine.anatomical_structure Cancer cell medicine.symptom General Agricultural and Biological Sciences Metabolic Networks and Pathways |
| Zdroj: | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 494(1) |
| ISSN: | 1608-3105 |
| Popis: | An integrated microscopic study of the destruction of mouse Ehrlich ascites carcinoma (EAC) cells under starvation conditions has been carried out. It has been found that, in addition to apoptosis, necrosis, and apoptotic necrosis, already known for EAC, cell destruction can also occur through mitochondrial autolysis, which is proposed to be considered a new kind of mitoptosis. A mitoptosis in EAC is characterized by the appearance of many autolyzing mitochondria, the fusion of which leads to rupture of the cell membrane and the ejection of the nucleus from the cell. It is assumed that the polymorphism of EAC destruction patterns is explained by the different physiological state of the cells, which determines the "choice" of the cell death mechanism. This situation poses a challenge for researchers to develop complex inducers with the ability to stimulate all possible types of cancer cell death. |
| Databáze: | OpenAIRE |
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