Chronic Sound-induced Tinnitus and Auditory Attention in Animals
| Autor: | Marc Randall, Kurt W. Wisner, Thomas J. Brozoski, Donald M. Caspary |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Selective auditory attention medicine.medical_specialty media_common.quotation_subject Nose poke Stimulus (physiology) Audiology Tinnitus 03 medical and health sciences 0302 clinical medicine Animal model Auditory attention Evoked Potentials Auditory Brain Stem otorhinolaryngologic diseases medicine Animals Attention Rats Long-Evans media_common Cued speech Behavior Animal business.industry General Neuroscience Sound 030104 developmental biology Acoustic Stimulation Hearing Loss Noise-Induced Conditioning Operant medicine.symptom business 030217 neurology & neurosurgery Vigilance (psychology) |
| Zdroj: | Neuroscience. 407:200-212 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2018.10.013 |
| Popis: | Attention may be an important factor in tinnitus. Individuals most disturbed by their tinnitus differ from those who are not in terms of attention allocation. This study used an operant-conditioning animal model to examine the interaction between tinnitus and auditory vigilant attention as well as auditory selective attention. Tinnitus was induced in 90-day-old rats by a unilateral exposure to band-limited noise (120 dB, SPL). Tinnitus testing began 90 days following exposure; afterward animals were divided into three groups: Unexposed controls without tinnitus, Exposed without tinnitus, and Exposed with tinnitus. Tinnitus was evident in the vicinity of 20 kHz. Vigilant attention was quantified by the behavioral (operant) response to unpredictable sound transitions signaling changes in food availability. Tinnitus animals were more vigilant, i.e., responded more rapidly, to 20-kHz tone onsets than Unexposed or Exposed animals without tinnitus. There were no significant vigilant attention differences between groups to non-tinnitus like sounds. The same animals were further trained and tested on a selective attention task. A brief free-field sound cue, consisting of either a short train of identical noise pulses (standard stimulus), or a noise train with one substituted tone pulse (oddball stimulus), cued a left or right nose poke for food. On this selective attention task, Tinnitus animals performed consistently worse than Non-tinnitus or Unexposed control animals regardless of stimulus features. As predicted, animals with behavioral evidence of tinnitus showed tinnitus-related attentional changes, including impaired selective attention but increased vigilance to sounds approximating their tinnitus. |
| Databáze: | OpenAIRE |
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