Correlation of the Glomerular Filtration Rate Measured With the Use of DTPA-Tc99m in Live Kidney Donors With Equations Based on Creatinine and Cystatin C

Autor: I. Castro, H. Diliz, P. Prieto, J. Barragan, A. Garcia, C Alejandra, A Reding, H. Hinojosa, Luis García-Covarrubias, Marco Antonio Carmona, D. Ortuño, D. Fernandez, K. Hernández
Rok vydání: 2018
Předmět:
Male
medicine.medical_treatment
030232 urology & nephrology
Kidney
Kidney Function Tests
urologic and male genital diseases
Nephrectomy
Body Mass Index
chemistry.chemical_compound
Postoperative Complications
0302 clinical medicine
Living Donors
Postoperative Period
030212 general & internal medicine
reproductive and urinary physiology
Kidney transplantation
biology
Middle Aged
female genital diseases and pregnancy complications
medicine.anatomical_structure
Creatinine
Technetium Tc 99m Pentetate
Female
Cystatin
Glomerular Filtration Rate
Adult
medicine.medical_specialty
Urology
Renal function
03 medical and health sciences
medicine
Humans
Cystatin C
Renal Insufficiency
Chronic
Radionuclide Imaging
Aged
Transplantation
urogenital system
business.industry
medicine.disease
Kidney Transplantation
Cross-Sectional Studies
chemistry
Linear Models
biology.protein
Surgery
Radiopharmaceuticals
business
Kidney disease
Zdroj: Transplantation Proceedings. 50:423-427
ISSN: 0041-1345
DOI: 10.1016/j.transproceed.2017.12.039
Popis: Background Renal donation leads to a risk of developing chronic kidney disease, with an incidence of 0.47%. To evaluate for its presence, formulas based on serum creatinine are used, but up to 80% of these formulas underestimate the glomerular filtration rate (GFR) in donors. The aim of this work was to confirm the highest correlation of the GFR as measured with the use of DTPA-Tc99m with the GFR as estimated by means of the formula based on serum cystatin C (CKD-EPI creatinine–cystatin C) in healthy kidney donors. Methods In this observational, analytic, cross-sectional study, the GFR of kidney donors was determined ≥1 year after donation by means of DTPA gammagram and estimation with the use of conventional formulations and with cystatin C. Results Of 112 donors, 38 (34%) were included, 20 (60%) were female, with an overall average age of 40 years, 36.5 months after donation, and body mass index of 25.5 kg/m2. Correlation with the GFR as measured by means of DTPA gammagram was better with the use of CKD-EPI cystatin C (0.402; P = .020) and CKD-EPI creatinine-cystatin (0.549; P Conclusions There is a strong correlation between estimate the GFR by equations based on cystatin C and the measurement of the GFR by DTPA-Tc99m gammagram.
Databáze: OpenAIRE
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