Acute leukemia with t(1;3)(p36;q21), evolution to t(1;3)(p36;q21),t(14;17)(q32;q21), and loss of red cell A and Leb antigens
| Autor: | R I Kimber, Derek S. Ford, Sandra Heard, Graham G. Collins, Anne Maree Pearse, Katherine Marsden |
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| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
Myeloid Biology Translocation Genetic ABO Blood-Group System Immunophenotyping Lewis Blood Group Antigens Antigen Antigens CD Antigens Neoplasm hemic and lymphatic diseases Genetics medicine Humans neoplasms Molecular Biology Aged Chromosomes Human Pair 14 Acute leukemia Red Cell Gene Expression Regulation Leukemic Adenylate Kinase Anemia Refractory Chromosomes Human 1-3 medicine.disease Molecular biology Leukemia Myeloid Acute Leukemia Cell Transformation Neoplastic medicine.anatomical_structure Blood Grouping and Crossmatching Karyotyping Refractory anemia with ring sideroblasts Immunology Female Bone marrow Chromosomes Human Pair 17 |
| Zdroj: | Cancer Genetics and Cytogenetics. 64:80-85 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(92)90328-6 |
| Popis: | At transformation of refractory anemia with ring sideroblasts to acute nonlymphocytic leukemia (ANLL) the bone marrow cells of a 75-year-old woman showed three different karyotypes, i.e., 46,XX,46,XX,t(1;3)(p36;q21) and 46,XX,t(1;3)(p36;q21),t(14;17)(q32;q21). She received no antileukemic therapy, and 1 year later, all her bone marrow cells were t(1;3)(p36;q21),t(14;17)(q32;q21). In association with the onset and first 11 months of ANLL, the platelet count increased 10-fold to a peak of 750 x 10(9)/L, providing further evidence that the t(1;3)(p36;q21) translocation causes stimulation of thrombopoiesis. Six months after transformation, her red cells showed reduced expression of A and Leb antigens. Serum alpha-n-3-acetylgalactosaminyl transferase (blood group A transferase) and red cell adenylate kinase were both reduced. The genes for both these substances are at 9q34, which suggests an abnormality here, although cytogenetically chromosome 9 appeared normal. This is the first case with t(1;3)(p36;q21) to show concurrent loss of red cell antigens and the first report detailing the course of untreated ANLL with t(1;3)(p36;q21). |
| Databáze: | OpenAIRE |
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