Cytokine and C-Reactive Protein Profiles Induced by Porcine Circovirus Type 2 Experimental Infection in 3-Week-Old Piglets
| Autor: | Deirdre Gilpin, Kenneth C. McCullough, Leanne Stevenson, B. M. Adair, Artur Summerfield, Gordon Allan, Jens Nielsen, Isabelle Vincent, Francis McNeilly |
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| Rok vydání: | 2006 |
| Předmět: |
Circovirus
Swine animal diseases medicine.medical_treatment Immunology Weaning Virology medicine Animals Wasting Syndrome Circoviridae Infections Swine Diseases integumentary system biology C-reactive protein virus diseases A protein biology.organism_classification Porcine circovirus C-Reactive Protein Cytokine Animals Newborn biology.protein Cytokines Molecular Medicine |
| Zdroj: | Viral Immunology. 19:189-195 |
| ISSN: | 1557-8976 0882-8245 |
| DOI: | 10.1089/vim.2006.19.189 |
| Popis: | The purpose of this study was to determine serum profiles of cytokines at a protein level and Creactive protein (CRP) during the development of postweaning multisystemic wasting syndrome (PMWS) in experimentally inoculated pigs. Levels of serum IFN-alpha, IL-6, IL-10, and CRP were examined for a 35-day period in 10 piglets experimentally infected with PCV2 at 3 weeks of age. Four of the infected piglets developed severe PMWS at 14 to 21 days post-infection (d.p.i.) and died prior to termination of the experiment. The remaining six PCV2-infected piglets experienced transient fever, but did not display overt clinical signs of PMWS and were considered as subclinically infected. A bioassay was used to detect IL-6 and ELISAs were used to detect IFN-alpha, IL-10, and CRP. There were no significant differences in cytokine or CRP expression from 0 to 7 d.p.i. between the PMWS-affected and the subclinically infected piglets. Levels of IL-10 and CRP were elevated from 10 and 14 d.p.i. respectively in the PMWS-affected piglets compared to the subclinically infected piglets. There were no significant differences in IFN-alpha and IL-6 expression between the PMWS-affected piglets and the subclinically infected piglets. The present study shows that elevated levels of serum CRP and IL-10 were associated with PCV2-infected piglets that subsequently developed severe PMWS. This may help to provide further insight into the immunoaetiogenesis of this syndrome. |
| Databáze: | OpenAIRE |
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