Merkel Cell Carcinoma With Isolated Pancreatic Metastasis
| Autor: | Prasanth Lingamaneni, Aleksandar Krbanjevic, Vatsala Katiyar, hisham laswi, Shweta Gupta, Krishna Rekha Moturi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Endoscopic ultrasound
Male Pathology medicine.medical_specialty Medicine (General) Skin Neoplasms Epidemiology medicine.medical_treatment Case Report Neuroendocrine tumors carcinoma Metastasis 03 medical and health sciences 0302 clinical medicine R5-920 Carcinoma Medicine RB1-214 metastasis Humans pancreas Safety Risk Reliability and Quality Etoposide Merkel Chemotherapy medicine.diagnostic_test business.industry Merkel cell carcinoma food and beverages Middle Aged medicine.disease Immunohistochemistry Carcinoma Merkel Cell Pancreatic Neoplasms medicine.anatomical_structure 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology immunotherapy Neoplasm Recurrence Local business Pancreas Safety Research medicine.drug |
| Zdroj: | Journal of Investigative Medicine High Impact Case Reports Journal of Investigative Medicine High Impact Case Reports, Vol 9 (2021) |
| ISSN: | 2324-7096 |
| Popis: | Merkel cell carcinoma (MCC) is a highly aggressive cutaneous neuroendocrine carcinoma, frequently associated with distant metastasis. However, recurrence of MCC manifesting with only pancreatic involvement is exceedingly rare. A 53-year-old man presented to our institution with abdominal discomfort 3 months after initial resection of chest wall MCC. Imaging revealed lesions in the pancreas and peripancreatic lymph nodes. Pathology obtained through endoscopic ultrasound confirmed recurrence of MCC. He underwent chemotherapy with cisplatin and etoposide, resulting in a complete resolution of the pancreatic lesions. Unfortunately, he passed away from sudden cardiac arrest while being in remission from MCC. Immunohistochemistry is crucial in differentiating MCC from primary pancreatic glandular and neuroendocrine tumors. While there are no definitive guidelines in the management of pancreatic lesions associated with MCC, checkpoint inhibitor immunotherapy is increasingly being used. |
| Databáze: | OpenAIRE |
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