The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population: a two-year follow-up
| Autor: | Fei Yuan, Min Han, Hong Li, Kwok-Yung Yuen, Min Zhao, Xia Peng, Yu Bai, Yingze Zhao, Wen Xu, George F. Gao, Honglan Zhao, Joseph O. Obameso, Shiyan Zhu, Canping Huang, Yuhui Zhao, Hao Jia, Wenjie Tan, William J. Liu, Lin Lu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
China animal structures South china Genes Viral viruses Population coronavirus Zoology Genome Viral Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology law.invention Evolution Molecular 03 medical and health sciences Cave law Chiroptera evolution Prevalence bat population medicine Animals education Gene Phylogeny General Environmental Science Coronavirus Recombination Genetic education.field_of_study geography geography.geographical_feature_category Sequence Analysis DNA 030104 developmental biology Viral evolution Natural source Recombinant DNA RNA Viral Coronavirus Infections General Agricultural and Biological Sciences Follow-Up Studies Research Paper |
| Zdroj: | Science China. Life Sciences |
| ISSN: | 1869-1889 1674-7305 |
| DOI: | 10.1007/s11427-017-9263-6 |
| Popis: | Bats are connected with the increasing numbers of emerging and re-emerging viruses that may break the species barrier and spread into the human population. Coronaviruses are one of the most common viruses discovered in bats, which were considered as the natural source of recent human-susceptible coronaviruses, i.e. SARS-COV and MERS-CoV. Our previous study reported the discovery of a bat-derived putative cross-family recombinant coronavirus with a reovirus gene p10, named as Ro-BatCoV GCCDC1. In this report, through a two-year follow-up of a special bat population in one specific cave of south China, we illustrate that Ro-BatCoV GCCDC1 persistently circulates among bats. Notably, through the longitudinal observation, we identified the dynamic evolution of Ro-BatCoV GCCDC1 in bats represented by continuously recombination events. Our study provides the first glimpse of the virus evolution in one longitudinally observed bat population cohort and underlines the surveillance and pre-warning of potential interspecies transmittable viruses in bats. |
| Databáze: | OpenAIRE |
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