Morphine acts on spinal dynorphin neurons to cause itch through disinhibition
Autor: | Sarah E. Ross, Grace Lim, Huiping Ding, Junichi Hachisuka, Eileen Nguyen, Mei-Chuan Ko |
---|---|
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Side effect Spinal morphine Sensory system Dynorphin Dynorphins law.invention Mice 03 medical and health sciences 0302 clinical medicine immune system diseases law parasitic diseases otorhinolaryngologic diseases medicine Animals Humans In patient skin and connective tissue diseases Neurons Clinical pharmacology Morphine business.industry Pruritus General Medicine eye diseases Analgesics Opioid 030104 developmental biology Disinhibition medicine.symptom business Neuroscience 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Science Translational Medicine. 13 |
ISSN: | 1946-6242 1946-6234 |
Popis: | Morphine-induced itch is a very common and debilitating side effect that occurs in laboring women who receive epidural analgesia and in patients who receive spinal morphine for relief of perioperative pain. Although antihistamines are still widely prescribed for the treatment of morphine-induced itch, their use is controversial because the cellular basis for morphine-induced itch remains unclear. Here, we used animal models and show that neuraxial morphine causes itch through neurons and not mast cells. In particular, we found that spinal dynorphin (Pdyn) neurons are both necessary and sufficient for morphine-induced itch in mice. Agonism of the kappa-opioid receptor alleviated morphine-induced itch in mice and nonhuman primates. Thus, our findings not only reveal that morphine causes itch through a mechanism of disinhibition but also challenge the long-standing use of antihistamines, thereby informing the treatment of millions worldwide. |
Databáze: | OpenAIRE |
Externí odkaz: |