Biocompatibility of sorbitol-containing polyesters. Part I: Synthesis, surface analysis and cell response in vitro
| Autor: | S B. Kennedy, Newell R. Washburn, Wei Gao, Eric J. Amis, John T. Elliott, Richard A. Gross, Ying Mei, Ashok Kumar |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Materials science
Condensation polymer Biocompatibility Cell Survival Surface Properties Polyesters Molecular Conformation Biophysics Biocompatible Materials Bioengineering Biomaterials Contact angle Mice chemistry.chemical_compound Tissue engineering Cell Movement Materials Testing Polymer chemistry Cell Adhesion Animals Sorbitol Thin film Cell Size Spin coating Tissue Engineering technology industry and agriculture 3T3 Cells Polyester Chemical engineering chemistry Mechanics of Materials Ceramics and Composites Caprolactone Cell Division |
| Zdroj: | Biomaterials. 25:4195-4201 |
| ISSN: | 0142-9612 |
| Popis: | A series of sorbitol-containing polyesters were synthesized via a one-pot lipase-catalyzed condensation polymerization. Thin films were prepared by spin coating on silicon wafers and surfaces were analyzed by tapping mode atomic force microscopy and contact angle measurements. Surface morphologies and surface energies across the series of polyester films, including a poly( e -caprolactone) (PCL) control were nearly indistinguishable. Biocompatibility of the sorbitol-containing polyester series was evaluated against a PCL control by measuring cell spreading and proliferation of a mouse fibroblast 3T3 cell line in vitro. Results confirmed that the sorbitol-containing polyester surfaces elicited cell behavior similar to the PCL control. These results establish the sorbitol-containing polyester series as a promising material for tissue engineering research and development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect