Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla
| Autor: | Dushyant Kumar, Russell T. Shinohara, Ravi Prakash Reddy Nanga, Qin Qin, Ravinder Reddy, Dan Zhu, Neil Wilson, Melissa Lynne Martin, Deepa Thakuri, Abigail Cember, Hari Hariharan |
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| Rok vydání: | 2020 |
| Předmět: |
Coefficient of variation
Kinetics Creatine Article Plantar flexion 030218 nuclear medicine & medical imaging Phosphocreatine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Peroneus longus Humans Medicine Radiology Nuclear Medicine and imaging Muscle Skeletal Exercise biology business.industry Repeatability Magnetic Resonance Imaging chemistry biology.protein Creatine kinase Nuclear medicine business 030217 neurology & neurosurgery |
| Zdroj: | Magn Reson Med |
| ISSN: | 1522-2594 0740-3194 |
| Popis: | Purpose Two-dimensional creatine CEST (2D-CrCEST), with a slice thickness of 10-20 mm and temporal resolution (τRes ) of about 30 seconds, has previously been shown to capture the creatine-recovery kinetics in healthy controls and in patients with abnormal creatine-kinase kinetics following the mild plantar flexion exercise. Since the distribution of disease burden may vary across the muscle length for many musculoskeletal disorders, there is a need to increase coverage in the slice-encoding direction. Here, we demonstrate the feasibility of 3D-CrCEST with τRes of about 30 seconds, and propose an improved voxel-wise B 1 + -calibration approach for CrCEST. Methods The current 7T study with enrollment of 5 volunteers involved collecting the baseline CrCEST imaging for the first 2 minutes, followed by 2 minutes of plantar flexion exercise and then 8 minutes of postexercise CrCEST imaging, to detect the temporal evolution of creatine concentration following exercise. Results Very good repeatability of 3D-CrCEST findings for activated muscle groups on an intraday and interday basis was established, with coefficient of variance of creatine recovery constants (τCr ) being 7%-15.7%, 7.5%, and 5.8% for lateral gastrocnemius, medial gastrocnemius, and peroneus longus, respectively. We also established a good intraday and interday scan repeatability for 3D-CrCEST and also showed good correspondence between τCr measurements using 2D-CrCEST and 3D-CrCEST acquisitions. Conclusion In this study, we demonstrated for the first time the feasibility and the repeatability of the 3D-CrCEST method in calf muscle with improved B 1 + correction to measure creatine-recovery kinetics within a large 3D volume of calf muscle. |
| Databáze: | OpenAIRE |
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